diff --git a/conf/searx.ini b/conf/searx.ini
index 5b503d4..72b60cc 100644
--- a/conf/searx.ini
+++ b/conf/searx.ini
@@ -12,13 +12,16 @@ chmod-socket = 666
 # Plugin to use and interpretor config
 single-interpreter = true
 master = true
-plugin = python
+plugin = python3
 lazy-apps = true
 enable-threads = true
 
 # Application base folder
 base = __FINALPATH__
 
+# Support running the module from a webserver subdirectory.
+route-run = fixpathinfo:
+
 # Module to import
 module = __APP__.webapp
 
diff --git a/scripts/_common.sh b/scripts/_common.sh
index 1ef3de8..03febb9 100644
--- a/scripts/_common.sh
+++ b/scripts/_common.sh
@@ -5,4 +5,4 @@
 #=================================================
 
 # dependencies used by the app
-pkg_dependencies="git build-essential libxslt-dev python-dev python-virtualenv python-cffi virtualenv python-babel zlib1g-dev libffi-dev libssl-dev python-lxml uwsgi uwsgi-plugin-python"
+pkg_dependencies="git build-essential libxslt-dev python3-dev python3-venv python3-cffi python3-babel zlib1g-dev libffi-dev libssl-dev python3-lxml uwsgi uwsgi-plugin-python3"
diff --git a/scripts/install b/scripts/install
index f6a1719..f151451 100644
--- a/scripts/install
+++ b/scripts/install
@@ -98,10 +98,10 @@ ynh_replace_string --match_string="werkzeug.contrib.fixers" --replace_string="we
 #=================================================
 ynh_script_progression --message="Installing Searx..."
 
-virtualenv --system-site-packages "$final_path"
+python3 -m venv "$final_path"
 set +u; source $final_path/bin/activate; set -u
-pip install -U setuptools
-pip install --requirement $final_path/requirements-ynh.txt
+pip3 install -U pip setuptools
+pip3 install --requirement $final_path/requirements-ynh.txt
 
 #=================================================
 # CONFIGURE SEARX
diff --git a/scripts/upgrade b/scripts/upgrade
index 9d2062a..646ec62 100644
--- a/scripts/upgrade
+++ b/scripts/upgrade
@@ -123,11 +123,12 @@ ynh_system_user_create --username=$app
 #=================================================
 ynh_script_progression --message="Upgrading Searx..." --weight=7
 
-rm -r $final_path/lib/python2.7/site-packages/setuptools $final_path/lib/python2.7/site-packages/setuptools-*
-virtualenv --system-site-packages "$final_path"
+# Clean venv if it still on python2
+test -e $final_path/bin/python3 || ynh_secure_remove --file=$final_path
+python3 -m venv "$final_path"
 set +u; source $final_path/bin/activate; set -u
-pip install -U setuptools
-pip install --requirement $final_path/requirements-ynh.txt --upgrade
+pip3 install -U pip setuptools
+pip3 install --requirement $final_path/requirements-ynh.txt --upgrade
 
 #=================================================
 # CONFIGURE SEARX