diff --git a/locales/en.json b/locales/en.json
index e48ba65ce..f4d4492ab 100644
--- a/locales/en.json
+++ b/locales/en.json
@@ -503,6 +503,7 @@
     "migration_0023_not_enough_space": "Make sufficient space available in {path} to run the migration.",
     "migration_0023_postgresql_11_not_installed": "PostgreSQL was not installed on your system. Nothing to do.",
     "migration_0023_postgresql_13_not_installed": "PostgreSQL 11 is installed, but not PostgreSQL 13!? Something weird might have happened on your system :(...",
+    "migration_0024_rebuild_python_venv_failed": "Unable to rebuild the python virtual env {venv}, this app is probably broken. If your app is broken, you probably should force the upgrade of this app thanks to `yunohost app upgrade --force APP`",
     "migration_description_0021_migrate_to_bullseye": "Upgrade the system to Debian Bullseye and YunoHost 11.x",
     "migration_description_0022_php73_to_php74_pools": "Migrate php7.3-fpm 'pool' conf files to php7.4",
     "migration_description_0023_postgresql_11_to_13": "Migrate databases from PostgreSQL 11 to 13",
diff --git a/src/migrations/0024_rebuild_python_venv.py b/src/migrations/0024_rebuild_python_venv.py
new file mode 100644
index 000000000..7d6530c8c
--- /dev/null
+++ b/src/migrations/0024_rebuild_python_venv.py
@@ -0,0 +1,74 @@
+import subprocess
+import os
+
+from moulinette import m18n
+from moulinette.utils.log import getActionLogger
+from moulinette.utils.process import call_async_output
+
+from yunohost.tools import Migration
+from yunohost.utils.filesystem import read_file, rm
+
+logger = getActionLogger("yunohost.migration")
+
+VENV_REQUIREMENTS_SUFFIX = ".requirements_backup_for_bullseye_upgrade.txt"
+VENV_IGNORE = "ynh_migration_no_regen"
+
+
+def _get_all_venvs(dir, level=0, maxlevel=3):
+    """
+        Returns the list of all python virtual env directories recursively
+
+        Arguments:
+            dir - the directory to scan in
+            maxlevel - the depth of the recursion
+            level - do not edit this, used as an iterator
+    """
+    # Using os functions instead of glob, because glob doesn't support hidden
+    # folders, and we need recursion with a fixed depth
+    result = []
+    for file in os.listdir(dir):
+        path = os.path.join(dir, file)
+        if os.path.isdir(path):
+            if os.path.isfile(os.path.join(path, VENV_IGNORE)):
+                continue
+            activatepath = os.path.join(path, "bin", "activate")
+            if os.path.isfile(activatepath):
+                content = read_file(activatepath)
+                if ("VIRTUAL_ENV" in content) and ("PYTHONHOME" in content):
+                    result.append(path)
+                    continue
+            if level < maxlevel:
+                result += _get_all_venvs(path, level=level + 1)
+    return result
+
+
+class MyMigration(Migration):
+    """
+    After the update, recreate a python virtual env based on the previously
+    generated requirements file
+    """
+
+    dependencies = ["migrate_to_bullseye"]
+
+    def run(self):
+
+        venvs = _get_all_venvs("/opt/") + _get_all_venvs("/var/www/")
+        for venv in venvs:
+            if not os.path.isfile(venv + VENV_REQUIREMENTS_SUFFIX):
+                continue
+
+            # Recreate the venv
+            rm(venv, recursive=True)
+            callbacks = (
+                lambda l: logger.info("+ " + l.rstrip() + "\r"),
+                lambda l: logger.warning(l.rstrip())
+            )
+            call_async_output(["python", "-m", "venv", venv], callbacks)
+            status = call_async_output([
+                "{venv}/bin/pip", "install", "-r",
+                venv + VENV_REQUIREMENTS_SUFFIX], callbacks)
+            if status != 0:
+                logger.warning(m18n.n("migration_0024_rebuild_python_venv",
+                                      venv=venv))
+            else:
+                rm(venv + VENV_REQUIREMENTS_SUFFIX)